Asian Journal of Orthopaedic Research <p style="text-align: justify;"><strong>Asian Journal of Orthopaedic Research</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJORR/general-guideline-for-authors">Click here for Types of paper</a>) on all aspects of&nbsp;Orthopaedic&nbsp;research. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> Asian Journal of Orthopaedic Research en-US Asian Journal of Orthopaedic Research Case Study on Langerhans Cell Histiocytosis of Bone <p><strong>Aims: </strong>To precise, the epidemiological, clinical, para-clinical, therapeutic and prognostic characteristics of skeletal involvement in Langerhans cell histiocytosis</p> <p><strong>Materials and Methods: </strong>A retrospective and descriptive study of patients with Langerhans cell histiocytosis admitted in Internal Medicine Departments of Hedi Chaker University Hospital of Sfax between 1996 and 2018. Cases of Langerhans cell histiocytois confirmed with histo- pathological examination were included.</p> <p><strong>Results: </strong>Four cases of LCH with bone involvement were noted. All patients enrolled were male and the mean age at diagnosis was 23.25 years. The bone lesions were unifocal in two cases and multifocal with multisystemic LCH in the others. The treatment consisted of curettage in two cases and two patients received systemic therapy with corticosteroids and vinblastine respectively. The outcome was favorable in two patients with eosinophilic ganuloma and systemic replases were noted with novel bone lesions in two patients presenting the systemic form of the disease.</p> <p><strong>Conclusion: </strong>LCH is a rare disease in children and young adult males. In the present series, bone was the most frequently involved site. The circumstances of discovery of bone localization were the pain swelling lesion in different sites. Biopsy is necessary to obtain diagnosis confirmation. The prognosis of this pathology depends largely on early diagnosis, other organs affected and the response to treatment. The new class of BRAF inhibitors may be a promising therapeutic option in LCH which needs to be assessed in prospective studies mainly in bone lesions.</p> Mouna Djerbi Mouna Snoussi Hela Mnif Faten Frikha Sameh Marzouk Tahya Sallemi Boudawara Zeineb Mnif Zouhir Bahloul ##submission.copyrightStatement## 2019-08-24 2019-08-24 1 10 Study of Functional Outcome of Three or Four Part Proximal Humerus Fracture Treated with Primary Hemiarthroplasty <p><strong>Introduction: </strong>The treatment of displaced proximal humerus fracture is challenging and at the same time controversial. It varies from conservative to surgical management. Primary hemiarthroplasty in proximal humerus fracture is indicated in three or four part fracture or fracture dislocations. Main aims of treatment in open reduction and internal fixation are preservation of vascularity of humeral head and an anatomical reduction of fracture, which is difficult in three or four part fractures of proximal humerus. Hence we studied functional outcome of 3 or 4 part proximal humerus fracture treated with primary hemiarthroplasty.</p> <p><strong>Materials and Methods: </strong>Fifteen patients diagnosed with three or four part proximal humerus fracture underwent primary hemiarthroplasty between January 2017 and June 2018. Functional evaluation based on constant score and radiological assessments by periodic X-rays were done. All patients were operated in a ‘beach chair position’. The lesser and greater tuberosity were dissected with their tendinous attachments and were later reattached to the proximal humerus for stability of the prosthesis.</p> <p><strong>Results: </strong>Mean follow up was 14.3 months (range 11-18 months). Mean age was 61.20 years (range 48–78 years). Ten patients were male and five were female. Mean Constant score was 55.25 (range 43.2-64.4) points at final follow up. . Mean anterior elevation was 119.5°(range 75<sup>0</sup>-150<sup>0</sup>). Mean active abduction was 104° (range 57° - 130°). Mean external rotation was 24° (range 16º - 30º). Proximal migration of tuberosity was present in two patients. Two patients had moderate pain at their final follow up. Twelve (i.e., 80%) patients were satisfied about their functional outcome.</p> <p><strong>Conclusion: </strong>The study showed hemiarthroplasty is a better option in treating proximal humerus fracture in elderly but also is a viable alternative to osteosynthesis for grossly comminuted proximal humerus fractures in young adults.</p> Nitin S. Patil Rutvik Shah Amit B. Garud Vishal Sharma ##submission.copyrightStatement## 2019-09-16 2019-09-16 1 10