Asian Journal of Orthopaedic Research

Revolutionizing Arthritis Treatment: The Synergy of iPSCs and Extracellular Vesicles-based Acellular Therapies for Joint Tissue Repair

Owen R. Thornton *

Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Wenjun Li

Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA and Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

*Author to whom correspondence should be addressed.

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Abstract

This review discusses the current state of arthritis treatment and the limitations associated with traditional approaches. The review then explores the potential of induced pluripotent stem cells (iPSCs) and extracellular vesicles (EVs) for joint tissue repair. The use of iPSCs and EVs together in acellular therapies has the potential to provide a safe and effective treatment option for joint tissue repair. The review examines the benefits of these therapies and discusses future research directions, including the use of bioinspired EV-mimicking nanoparticles and the modulation of the immunogenicity of donor iPSCs. The review also addresses the potential ethical implications of these therapies and proposes solutions for addressing these concerns. Overall, this review suggests that iPSCs and EVs-based acellular therapies could revolutionize regenerative medicine for arthritis treatment, providing a promising avenue for future research.

Keywords: Osteoarthritis, acellular therapies, joint tissue repair, iPSCs treatment, ischemic diseases

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