Advancements in Engineering for the Treatment of Joint Diseases
Owen R. Thornton
a Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Wenjun Li *
Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States and Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
*Author to whom correspondence should be addressed.
Abstract
Joint diseases such as osteoarthritis are a significant burden on healthcare systems worldwide, and current treatments have numerous limitations in terms of efficacy and side effects. However, advancements in engineering treatments, including tissue engineering and stem cell therapy, have shown promise in providing better solutions for joint disease treatment. Biomaterials, growth factors, and synthetic polymers are being explored to create new tissues and organs, and genetic engineering and 3D printing have shown potential benefits in the field of engineering treatments. Nevertheless, developing new treatments is a complex and time-consuming process, and further clinical trials and improved infrastructure are needed to translate in vitro and preclinical data into clinical applications. Future directions for joint disease treatment engineering include the development of more biomimetic scaffolds and incorporation of stem cells to improve tissue regeneration.
Keywords: Joint diseases, tissue engineering, stem cell therapy, biomaterials, 3D printing
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References
Nanomaterials. (n.d.). Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis. Free Full-Text. Available:https://www.mdpi.com/411792 Accessed 2023-03-26.
Argenson JN, Boehler C. higher cumulative revision rate of knee arthroplasties in younger patients with osteoarthritis. Clinical Orthopaedics and Related Research (1976-2007); 2004.
Available:https://journals.lww.com/corr/Fulltext/2004/04000/Higher_Cumulative_Revision_Rate_of_Knee.27.aspx
Accessed 2023-03-26.
Khiavi MM, Khoshhal M, Ebrahimi M. Temporomandibular joint arthrocentesis and microfragmented adipose tissue injection for the treatment of internal derangement and osteoarthritis: A randomized clinical trial. Anesthesia/TMJ Disorders/Facial Pain; 2021. Available:https://www.sciencedirect.com/science/article/pii/S0278239121001063. Access on 2023-03-26
Goldring SR. Osteoarthritis — an untreatable disease? Nature Reviews Drug Discovery. 2003;2(7):583-586.
Available:https://www.nature.com/articles/nrd1693
van Buul GM, Koevoet WLM. Current treatment options for osteoarthritis. Ingenta Connect. 2018;14(2):107-116.
Available:https://www.ingentaconnect.com/content/ben/crr/2018/00000014/00000002/art00005.
Burska AN, Roget K, Blits M. Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis. Cells. Free Full-Text. 2021;10(2):342. Available:https://www.mdpi.com/682278
Heilig MW, Yount R. Osteoarthritis: Diagnosis and therapeutic considerations. American Family Physician. 2002;65(5):841-848. Available:https://www.aafp.org/pubs/afp/issues/2002/0301/p841.html.
Bhumiratana S, Eton RE, Oungoulian SR. Contributions of stem cell engineering to new therapies for joint and bone diseases. In Soker S, Atala A (Eds.), Current Topics in Developmental Biology: Engineering Tissues and Organs. Elsevier. 2019:45-86. Available:https://www.sciencedirect.com/science/article/pii/B9780323919388000093.
Makris EA, Hadidi P. The knee meniscus: Structure–function, pathophysiology, current repair techniques, and prospects for regeneration. European Cells and Materials. 2011;22:193-212.
Available:https://www.sciencedirect.com/science/article/pii/S0142961211007022.
Lin Y, An J, Li Y, Zhang L, Zhao Y. Advancements and frontiers in the high performance of natural hydrogels for cartilage tissue engineering. Frontiers in Chemistry. 2020;8:53. Available:https://doi.org/10.3389/fchem.2020.00053
Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK. Advancing biomaterials of human origin for tissue engineering. Progress in Polymer Science. 2016;53:86-168. Available:https://doi.org/10.1016/j.progpolymsci.2015.07.011
Buckwalter JA, Mankin HJ. Tissue engineering principles in orthopaedic surgery: Clinical orthopaedics and related research®. Clinical Orthopaedics and Related Research. 1999;367:S31-S42.
Available:https://doi.org/10.1097/00003086-199910001-00005
Ahmed M, Tariq M, Malik N, et al. Recent advancements in regenerative dentistry: A review. Materials Science and Engineering: C. 2017;76:1369-1382. Available:https://doi.org/10.1016/j.msec.2016.10.073
Madry H, van Dijk CN, Mueller-Gerbl M. The basic science of the subchondral bone. Knee Surgery, Sports Traumatology, Arthroscopy. 2010;18(4):419-433. Available:https://doi.org/10.1007/s00167-010-1053-9
Salzmann GM, Sah B, Sadoghi P, et al. Articular cartilage repair: Current needs, methods and research directions. Archives of Orthopaedic and Trauma Surgery. 2010;130(6):765-777. Available:https://doi.org/10.1007/s00402-010-1038-8
Einhorn TA, Gerstenfeld LC. Bone regeneration: current concepts and future directions. BMC Medicine. 2011;9(1):66. Available:https://doi.org/10.1186/1741-7015-9-66
Gao N, Li B, Wei X, Zhang J. Mapping tribo-corrosion processes in dry and in aqueous conditions: Some new directions for the new millennium. Wear. 2002;253(5-6):501-511. Available:https://doi.org/10.1016/S0301-679X(02)00059-2
Abdullah Al Zaki A, Nassani MZ, Hassan A, et al. Role of dental pulp stem cells in regenerative medicine: A journey of 10 years. International Journal of Dentistry. 2022;2022:9696378. Available:https://doi.org/10.1155/2022/9696378
Hossain MZ, Rahman MT, Hussain MS, et al. Stem cells in the treatment of diabetes mellitus: A systematic review and meta-analysis of animal studies. Stem Cells International. 2020;2020:8810813. Available:https://doi.org/10.1155/2020/8810813