High Dose-Short Duration Therapy of Cholecalciferol as a New Therapeutic Approach in the Treatment of Chronic Low Back Pain Associated with Vitamin D Deficiency

Khan Hasnat Iqbal *

Medical and Scientific Affairs, Pulse Pharmaceuticals, Hyderabad, India.

Harsh Chaturvedi

Medical and Scientific Affairs, Pulse Pharmaceuticals, Hyderabad, India.

Sumangal Ghatak

Medical and Scientific Affairs, Pulse Pharmaceuticals, Hyderabad, India.

Jyothsna Kuralla

Medical and Scientific Affairs, Pulse Pharmaceuticals, Hyderabad, India.

*Author to whom correspondence should be addressed.


Abstract

Chronic low back pain (CLBP) is a significant health issue, often linked to widespread vitamin D deficiency, particularly in Indian populations where prevalence exceeds 70%. This review evaluates the efficacy and safety of Oral Cholecalciferol Nano-Syrup therapy of High-Dose, Short-Duration (60,000 IU/day for 10 days) versus Conventional Weekly Vitamin D supplementation (60,000 IU/week for 12 Week) for the treatment of Vitamin D deficiency associated with Chronic Low Back Pain. While weekly regimens achieve vitamin D sufficiency rates of 44–68%, the High-Dose, Short-Duration therapy of Nano-syrup therapy consistently attains 100% sufficiency within 10 days, alongside marked improvements in Visual Analog Scale (VAS) and Modified Oswestry Disability Questionnaire (MODQ) scores, with reductions of up to 75% and 40%, respectively. The High-Dose, Short-Duration approach also demonstrated a favorable safety profile, with no serious adverse events reported. These findings suggest that high-dose, short-duration vitamin D therapy offers a more effective and efficient alternative for managing vitamin D deficiency and associated CLBP, highlighting its potential for broader clinical application.

Keywords: Chronic low back pain, vitamin D deficiency, nano-syrup, high-dose therapy, cholecalciferol


How to Cite

Iqbal, Khan Hasnat, Harsh Chaturvedi, Sumangal Ghatak, and Jyothsna Kuralla. 2025. “High Dose-Short Duration Therapy of Cholecalciferol As a New Therapeutic Approach in the Treatment of Chronic Low Back Pain Associated With Vitamin D Deficiency”. Asian Journal of Orthopaedic Research 8 (1):1-6. https://doi.org/10.9734/ajorr/2025/v8i1204.

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